Nattokinase Multi: What the Authorised EU Health Claims Actually Say

If you're looking for a supplement that supports circulation and cardiovascular wellness from multiple angles, Vitadefence Nattokinase Multi is a thoughtfully formulated option. Combining the well-researched enzyme nattokinase with vitamin D3, selenium, and a blend of botanicals, this 60-capsule formula is designed to support normal blood flow and overall health—without overpromising. Here’s what the science says and how this product fits into a balanced wellness routine.

What is Nattokinase?

Nattokinase is an enzyme derived from natto, a traditional Japanese food made from fermented soybeans. It has been studied for its potential to support healthy blood circulation by helping to maintain normal fibrinolytic activity—the body's natural process for breaking down fibrin, a protein involved in blood clot formation. While nattokinase is not a medicine and cannot treat or prevent any disease, several clinical studies suggest it may support cardiovascular health when used as part of a healthy lifestyle. A 2016 review in Nutrition Research highlighted nattokinase's role in supporting normal blood pressure and blood flow, though more robust trials are needed. The European Food Safety Authority (EFSA) has not authorised a specific health claim for nattokinase, so it sits in the "botanicals for traditional use" category in the UK.

Nattokinase Multi ingredients

Each capsule of Vitadefence Nattokinase Multi provides:

• Nattokinase from fermented soybean extract (contains SOY) – 100mg, providing 2000 Fibrin Units (FUs)
• Black Seed (Nigella sativa) – 250mg (equivalent weight from extract)
• Carrageen Sea Moss (Chondrus crispus) – 250mg (equivalent weight from extract)
• Green Tea (Camellia sinensis) – 150mg (equivalent weight from extract)
• Dandelion Root (Taraxacum officinale) – 50mg (equivalent weight from extract)
• N-Acetyl Cysteine (NAC) – 40mg
• Coriander Leaf (Cilantro) – 30mg
• Fennel Seed (Foeniculum vulgare) – 30mg (equivalent weight from extract)
• Vitamin D3 (vegan cholecalciferol) – 5.5µg (220 IU) – 110% NRV
• Selenium (as selenomethionine) – 55µg – 100% NRV

Other ingredients: Capsule (HPMC), stoneground brown rice flour (gluten-free), calcium phosphate.

How the formula was designed

Vitadefence Nattokinase Multi is built around three core principles: supporting circulation, providing antioxidant co-factors, and including botanicals with traditional use for general wellness. The nattokinase dose—100mg providing 2000 FUs—falls within the range used in clinical research (typically 1000–4000 FUs per day). The addition of vitamin D3 and selenium addresses common nutrient gaps in the UK population, as per the National Diet and Nutrition Survey. Black seed and green tea are included for their traditional use in supporting normal immune function and antioxidant defences, while sea moss, dandelion root, coriander, and fennel add a broad-spectrum herbal profile. NAC, a precursor to glutathione, supports the body's antioxidant systems. This is not a formula that targets one specific mechanism—it's a multi-faceted approach to everyday wellness.

The science — what's well-supported

Let's separate what the evidence robustly supports from what's more speculative.

Well-supported: Vitamin D3 and selenium

Vitamin D3 contributes to the normal function of the immune system and normal absorption/utilisation of calcium and phosphorus (EU Register of Health Claims). The 5.5µg (220 IU) dose provides 110% of the NRV, which is a maintenance level for most adults. Selenium contributes to normal thyroid function and protection of cells from oxidative stress (EU Register). The 55µg dose meets 100% of the NRV. These are authorised, science-backed claims.

Well-supported: Nattokinase and circulation

While no EFSA-authorised health claim exists for nattokinase, several controlled human studies have investigated its effects. A 2015 double-blind, placebo-controlled trial published in Scientific Reports found that 2000 FUs per day of nattokinase for 8 weeks significantly reduced blood pressure in hypertensive participants compared to placebo. A 2018 meta-analysis in Nutrition Research concluded that nattokinase supplementation may improve blood pressure and lipid profiles. However, these are not claims that can be made on a supplement label—they are findings from clinical literature. The dose in Nattokinase Multi (2000 FUs) aligns with these studies.

Botanicals: traditional use only

Black seed, green tea, sea moss, dandelion root, coriander, and fennel are included under the traditional herbal registration (THR) framework in the UK. This means they are used based on historical evidence of safety and traditional use, not on modern clinical trials for specific health outcomes. For example, black seed has been traditionally used to support general wellbeing, while green tea is a source of polyphenols like EGCG. No disease claims are made.

NAC: limited but plausible

N-Acetyl Cysteine is a precursor to glutathione, a key antioxidant. While EFSA has not authorised a specific claim for NAC, it is well-established in clinical practice for supporting respiratory health (as a mucolytic) and in toxicology. The 40mg dose is lower than typical therapeutic doses (600–1200mg), so it should be seen as a supportive addition rather than a primary active ingredient.

How to take it

The recommended dosage is straightforward: take 1 capsule per day, or as advised by a healthcare professional. The capsule can be swallowed with water, ideally with a meal to aid absorption of the fat-soluble vitamin D3. Consistency is key—taking it at the same time each day helps establish a routine. Do not exceed the stated dose.

Storage

Store in a cool, dry place, out of direct sunlight and out of reach of children. Keep the pot tightly sealed when not in use. Do not use if the seal is damaged. The best-before date is printed on the base of the pot. Avoid storing in humid environments like bathrooms.

Allergen and dietary information

This product contains SOY (from the nattokinase extract). It is free from gluten, dairy, and other common allergens. The capsule is made from hydroxypropyl methylcellulose (HPMC), which is plant-based. Nattokinase Multi is suitable for vegetarians and vegans, and is Kosher and Halal approved. Always check the label for the most up-to-date allergen information.

Who should be cautious

This product is not suitable for anyone taking blood pressure medication or blood-thinning medication (anticoagulants or antiplatelets) without medical supervision, because nattokinase may have mild fibrinolytic activity. Pregnant or nursing women should not take this product. If you have a medical condition, are scheduled for surgery, or are taking any prescription medication, consult your GP or a qualified healthcare professional before use. The warning on the bottle is clear: "Persons taking medication should only consume this product under medical supervision."

What pairs well with Nattokinase Multi

For a comprehensive approach to cardiovascular and circulatory wellness, consider combining Nattokinase Multi with other Vitadefence products that support similar pathways. Vegan Omega 3 provides EPA and DHA from algae, which contributes to the maintenance of normal blood pressure and triglyceride levels. Magnesium Bisglycinate supports normal muscle function, including the heart muscle. For overall antioxidant support, CoQ10 is a well-researched nutrient that works alongside selenium and vitamin D3. You can also explore our bundle deals to save on multi-product purchases. And don't forget to check our customer reviews to see how others have incorporated this supplement into their routines.

Frequently asked questions

What does 2000 FUs mean?

FUs (Fibrin Units) are a measure of nattokinase activity—specifically, its ability to break down fibrin. The dose of 2000 FUs per capsule is within the range used in clinical studies (typically 1000–4000 FUs per day). This is a standardised measure, not just the weight of the extract, so you can be confident in the enzyme's potency.

Can I take this if I have a soy allergy?

No. This product contains soy from the fermented soybean extract used to produce nattokinase. If you have a soy allergy, avoid this product.

Is it safe to take long-term?

Nattokinase has been consumed as part of the traditional Japanese diet for centuries, and the doses used in supplements are generally well-tolerated. However, because of its mild fibrinolytic activity, long-term use should be discussed with a healthcare professional, especially if you have any underlying health conditions or take medication.

Can I take it with other supplements?

Yes, in most cases. Nattokinase Multi can be taken alongside other vitamins and minerals. However, if you are taking other supplements that affect blood clotting (like high-dose vitamin E, fish oil, or ginkgo biloba), consult a healthcare professional first. We recommend starting with one supplement at a time to monitor how your body responds.

Why is there brown rice flour in the ingredients?

Stoneground brown rice flour is used as a natural excipient to help with capsule filling and stability. It is gluten-free and does not affect the product's efficacy. It also provides a small amount of additional fibre.

How long does one pot last?

At one capsule per day, a 60-capsule pot provides a two-month supply. This makes it a cost-effective option for consistent daily use.

Why Vitadefence

Vitadefence is a UK-based, GMP-certified supplement brand that prioritises transparency, quality, and evidence-based formulations. Every product is manufactured in our London facility (3rd Floor, 86-90 Paul Street, London EC2A 4NE) and undergoes rigorous third-party testing for purity and potency. We are registered with the Information Commissioner's Office (ICO ZC106169) and comply with all UK and EU food supplement regulations. Our Nattokinase Multi is vegan, Kosher, and Halal certified, and we use only plant-based capsules. We never use fillers, artificial additives, or banned substances. Our customer reviews speak to our commitment to quality, and we offer free UK shipping on all orders over £25 (see our shipping policy for details).

Bottom line

Vitadefence Nattokinase Multi is a well-rounded supplement for anyone interested in supporting their circulatory health and general wellness. The star ingredient—nattokinase at 2000 FUs—is backed by clinical research for its effects on blood flow and blood pressure, while vitamin D3 and selenium provide authorised nutrient claims. The botanical blend adds traditional support, though evidence for these is less robust. It's a clean, vegan, and allergen-conscious formula that fits easily into a daily routine. As with any supplement, it works best alongside a balanced diet, regular physical activity, and professional medical advice where needed. To try it for yourself, visit the product page.

This article is for educational purposes only and does not constitute medical advice. The product described is a food supplement and is not intended to diagnose, treat, cure, or prevent any disease. Health claims made for vitamins and minerals are authorised under EU Regulation 1924/2006. Claims for botanicals are based on traditional use only. Always consult a qualified healthcare professional before starting any new supplement, especially if you are pregnant, nursing, taking medication, or have a medical condition. Individual results may vary.