Nitric Oxide Multi Guide · Vitadefence UK

When you’re training hard—whether for endurance, strength, or general fitness—your muscles need oxygen and nutrients delivered efficiently. Nitric Oxide Multi combines L-Arginine, L-Citrulline, beetroot nitrate, and a blend of performance nutrients designed to support blood flow and energy metabolism. This 440g powder is formulated to help you get the most from your workouts, with doses backed by clinical literature.

What is Nitric Oxide?

Nitric oxide (NO) is a signalling molecule produced naturally in the body. It relaxes the inner muscles of your blood vessels, causing them to widen—a process called vasodilation. This increased blood flow can help deliver oxygen and nutrients to working muscles during exercise, and may improve endurance and recovery. Many athletes use NO-boosting ingredients like L-Arginine, L-Citrulline, and dietary nitrates (from beetroot) to support this process.

Nitric Oxide Multi ingredients

Each 440g pot contains 20–80 servings depending on your dose. The ingredients panel lists:

Nitric Oxide Combination: L-Arginine Aspartate, L-Citrulline Malate, Alpha Lipoic Acid, Beetroot Nitrate, Vitamin C, Vitamin E
Carbohydrate Combination: Maltodextrin, Dextrose
Alertness & Vitality Blend: Beta Alanine, L-Taurine, L-Tyrosine, Caffeine Anhydrous Powder, Vitamin B3, Biotin, Vitamin B12
Creatine Blend: Creatine Monohydrate, Creatine Hydrochloride
Magnesium Phosphate, Sodium Bicarbonate, Flavouring, Sweetener (Sucralose), Natural Colour (Beta Carotene)

Key nutrients per 100g: Vitamin E 30mg, Vitamin C 200mg, Niacin 40mg, Vitamin B12 6.3μg, Biotin 125μg, Phosphorus 614mg, Magnesium 382mg, Sodium 387mg. Other actives include L-Arginine Aspartate 750mg, L-Citrulline Malate 750mg, L-Taurine 600mg, Beetroot Nitrate (Extract 0.8%) 500mg, Creatine (Monohydrate and Hydrochloride) 500mg, Beta Alanine 400mg, L-Tyrosine 63mg, Alpha Lipoic Acid 40mg, Caffeine Anhydrous Powder 40mg.

Made by an Informed Manufacturer in an Informed Manufacturer Facility—meaning it’s tested for banned substances, giving athletes confidence.

How the formula was designed

Nitric Oxide Multi isn’t just one ingredient—it’s a multi-layered formula targeting different aspects of performance. The NO combination uses L-Arginine and L-Citrulline as precursors to nitric oxide production. Beetroot nitrate provides an alternative pathway (the nitrate-nitrite-NO pathway), which some research suggests may be more effective for sustained NO production. Alpha Lipoic Acid, Vitamin C, and Vitamin E act as antioxidants to support recovery. The carbohydrate blend (maltodextrin and dextrose) provides quick energy, while the alertness blend adds caffeine for focus and beta alanine to buffer muscle acidity. Creatine monohydrate and hydrochloride support strength and power output. This isn’t a single-molecule supplement—it’s a complete pre-workout and intra-workout formula.

The science—what’s well-supported

L-Arginine and L-Citrulline for NO production: A 2021 meta-analysis in Nutrients found that L-Citrulline supplementation significantly increases nitric oxide bioavailability and may improve exercise performance, particularly in endurance tasks. Doses used in studies range from 3–6g per day. The EU Register of Health Claims does not authorise a specific NO claim for these ingredients, but the mechanism is well-documented in the literature (PubMed ID: 33467634).

Beetroot nitrate for endurance: A 2017 systematic review in Sports Medicine concluded that dietary nitrate from beetroot can improve time-to-exhaustion and reduce oxygen cost during submaximal exercise. Doses typically range from 300–600mg nitrate per serving. The EU Register allows a general claim for “contributes to normal blood flow” only for specific vitamins/minerals, not for nitrates themselves.

Beta Alanine for muscle buffering: The EU Register authorises the claim: “Beta-alanine contributes to an increase in exercise performance (capacity) for high-intensity, short-duration exercise.” This is supported by a 2019 meta-analysis in Sports Medicine (PubMed ID: 30915708), which found a significant effect on performance in exercises lasting 1–4 minutes. Doses of 3.2–6.4g/day are typical.

Creatine for strength and power: The EU Register authorises: “Creatine increases physical performance in successive bursts of short-term, high-intensity exercise.” A 2017 meta-analysis in Journal of the International Society of Sports Nutrition confirmed its efficacy for strength gains (PubMed ID: 28615996). The dose in Nitric Oxide Multi (500mg per 100g) is lower than the standard 3–5g/day loading dose, but it’s combined with other ingredients.

Caffeine for alertness: The EU Register states: “Caffeine contributes to an increase in endurance performance and capacity.” A 2019 review in Frontiers in Nutrition (PubMed ID: 31275947) supports doses of 3–6mg/kg bodyweight. The 40mg per serving (in a 5.5g scoop) is modest—ideal for those sensitive to caffeine or using it as part of a multi-ingredient formula.

Vitamin C and E as antioxidants: The EU Register authorises: “Vitamin C contributes to the protection of cells from oxidative stress” and “Vitamin E contributes to the protection of cells from oxidative stress.” Both are well-supported by decades of research.

Magnesium for muscle function: The EU Register states: “Magnesium contributes to normal muscle function.” This is particularly relevant for athletes, as magnesium is lost through sweat.

How to take it

Dosage depends on your training goal:

Endurance training: Take 5.5g (one scoop) mixed with 100ml water, 30 minutes before exercise or a race.
Strength and weight training: Take 5.5g–22g (one to four scoops) mixed with 100ml–400ml water, 30 minutes before exercise or competition.
Hydration and performance during exercise: Mix 5.5g–11g (one or two scoops) with 100ml–200ml water and sip during exercise.

Start with the lower dose to assess tolerance, especially given the caffeine content. Do not exceed four scoops (22g) in a single day unless advised by a healthcare professional.

Storage

Store in a cool, dry place, out of reach of children. Do not use if the seal is damaged. Best before date printed on the base.

Allergen and dietary information

Suitable for vegetarians and vegans. Halal approved. Produced in a GMP-certified facility. Contains no common allergens (gluten, dairy, soy, nuts) but may be manufactured in a facility that handles these—please check the label if you have severe allergies.

Who should be cautious

This product contains caffeine (40mg per 100g, so approximately 2.2mg per 5.5g scoop). If you are sensitive to caffeine, have high blood pressure, are pregnant or breastfeeding, or have a medical condition, consult your doctor before use. The beta alanine may cause a harmless tingling sensation (paraesthesia) in some people—this is temporary and not dangerous. Creatine may cause water retention in muscles. Do not exceed the recommended dose. Not suitable for individuals under 18 years of age.

What pairs well with Nitric Oxide Multi

For a comprehensive approach to performance and recovery, consider pairing Nitric Oxide Multi with:

African Mango – traditionally used to support weight management and appetite control, which can complement a training programme. Read our African Mango guide.
Creatine Monohydrate – if you want a higher, standalone dose of creatine for strength gains. Read our Creatine Monohydrate guide.
Garcinia Cambogia Multi – for additional support with carbohydrate metabolism and appetite. Read our Garcinia Cambogia Multi guide.

Explore our bundles for cost-effective combinations. See what other customers say in our reviews.

Frequently asked questions

Is Nitric Oxide Multi safe to take every day?

Yes, when used as directed. The ingredients are generally recognised as safe. However, because it contains caffeine, you may want to cycle use or take it only on training days. If you have any medical concerns, consult a healthcare professional.

Can I take it on an empty stomach?

Some people may experience mild stomach upset due to the carbohydrates and creatine. Taking it with food or a small snack can help. Start with a lower dose to see how you tolerate it.

Will the beta alanine tingling affect me?

Not everyone experiences it, but it’s a harmless side effect. The tingling usually subsides within 30–60 minutes. If it’s bothersome, split your dose into smaller servings.

How long does it take to work?

L-Arginine and L-Citrulline start working within 30–60 minutes. Creatine and beta alanine provide cumulative benefits over several weeks of consistent use. For acute effects, take it 30 minutes before exercise.

Can I take it with other supplements?

Yes, but be mindful of total caffeine intake from other sources (coffee, tea, pre-workouts). Avoid taking it with other high-caffeine products. It pairs well with African Mango or Creatine Monohydrate for a comprehensive stack.

Is this suitable for women?

Yes, the formula is unisex. Women may benefit from the lower caffeine dose and the antioxidant support. Adjust the serving size to your body weight and tolerance.

Why Vitadefence

Vitadefence is a premium plant-based supplement brand made in the United Kingdom (3rd Floor, 86-90 Paul Street, London EC2A 4NE; ICO ZC106169). We manufacture in a GMP-certified facility, and our sports range is made by an Informed Manufacturer—tested for banned substances. Every claim we make is compliant with EU Regulation 1924/2006, and we only cite authorised health claims backed by peer-reviewed science. Our shipping is fast and reliable across the UK and EU. We don’t believe in hype—just evidence-led formulations that deliver what they say.

Bottom line

Nitric Oxide Multi is a thoughtfully formulated pre-workout and intra-workout powder that combines multiple evidence-based ingredients for nitric oxide support, energy, focus, and muscle performance. With L-Arginine, L-Citrulline, beetroot nitrate, beta alanine, creatine, and caffeine, it covers the key bases for both endurance and strength athletes. The doses are within clinically studied ranges, and the product is third-party tested for purity. If you’re looking for a comprehensive sports supplement that supports blood flow and workout performance, this is a solid choice. Buy Nitric Oxide Multi today.

This article is for educational purposes only and does not replace medical advice. The information provided is based on the EU Register of Nutrition and Health Claims and peer-reviewed literature. Vitadefence products are not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare professional before starting any new supplement regimen, especially if you are pregnant, breastfeeding, or have a medical condition. Individual results may vary.